1. | PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATION OF HYDRO ALCOHOLIC EXTRACT OF FRUITS OF TERMINALIA CHEBULA ON DIFFERENT ULCER-INDUCED MODELS |
| Rakesh Dhangar, Narendra Patel1 Hemant Kumar Sharma, Pradeep Kumar Patra |
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Article Type:Research Article/
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No of Download=384 |
Pages (4-10) |
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The objective of the present study is to study the effect of hydro alcoholic (70%) extract of Fruit of Terminalia chebula on gastric ulcers by using different experimental models such as aspirin induced ulcer, ethanol induced ulcers, cold restrain stress induced ulcers and pylorus ligation induced ulcers. In all these models the common parameter determined was ulcer index. The treatment with hydro alcoholic extract of Terminalia chebula at (500 mg/kg) significantly inhibited the gastric lesions induced by Aspirin induced gastric ulcer (85%), Ethanol induced gastric ulcer (72%), Cold restraint ulcer (79%), and Pylorus ligation induced ulcer (76%).The extracts (200 mg/kg and 500 mg/kg b.w.) showed a significant effect on ulcer by different ulcer induced models. These results may further suggest that hydro alcoholic extract was found to possess anti-ulcerogenic as well as ulcer healing properties, which might also be due to its antisecretory activity.
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2. | PHYTOCHEMICAL & ANALGESIC INVESTIGATION OF CALOTROPIS PROCERA LEAVES |
| Ankit Prajapati, Hemant Kumar Sharma, Pradeep Kumar Patra, Deepika Sahu |
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Article Type:Research Article/
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No of Download=744 |
Pages (11-15) |
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Preliminary phytochemical study of the petroleum ether, ethanolic and ethanolic extract of Calotropis procera, showed the presence of saponins, terpens, phenols, alkaloids, tannins and flavonoids. Different solvents (Petroleum ether, chloroform and ethanolic) are used for extraction of leaves of C. procera & were subjected for phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, cardiac glycosides, tri-terpenoids, phenolic compounds and tannins in the C. procera extract. The acute toxicity study revealed safely of the extract up to a dose of 2000 mg/kg in mice. The ethanolic, petroleum ether and chloroform extract of leaves of C. procera at a dose of 100, 200 and 500 mg/kg was selected for analgesic activity. Different extracts (Petroleum ether, chloroform and ethanolic) of leaves of C. procera were investigated for analgesic activity by using different models. The analgesic properties were studied on acetic acid induced writhing and tail flick latent period in rats. The result shows that the ethanolic extract of the leaves of C. procera was found to be effective
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3. | AN UP TO DATED OVERVIEW ON POLYCYSTIC OVARY SYNDROME (PCOS); CURRENT STATUS OF TREATMENTS IN VARIOUS SYSTEMS OF MEDICINES |
| Silpa.K.R, Jitty Jerry, Soumya.K.S and Dr.B.Rajinikanth |
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Article Type:Research Article/
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No of Download=386 |
Pages (16-22) |
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Polycystic ovary syndrome (PCOS) is a complex metabolic, endocrine and reproductive disorder affecting 5-10%of women of reproductive age. Irregular periods, acne, excessive hair growths are the common symptoms of PCOS.Prevalence of PCOS varies depending on the diagnostic criteria used. Insulin resistance, genetic factors, hormonalimbalance, high maternal androgen are the common predisposing factors associated with PCOS. PCOS is a multifacetedmetabolic disorder that shows a high association with insulin resistance leading to hyperinsulinemia. The main risk factorsfor PCOS include obesity, family history of infertility, diabetes & other psychological factors. Metabolic syndrome,cardiovascular complications, oncology, infertility are the complications associated with PCOS. PCOS can be managedthrough diet, exercise therapy, lifestyle modifications. National institutes of health criteria (NIH) defined in 1990, later in2003 the Rotterdam criteria used to diagnose PCOS. Allopathy, Ayurveda, Siddha, Homoeopathy and Acupuncture are thevarious systems of treatments used for PCOS. Allopathy does not cure PCOS, but helps in managing and controlling effectswhile in Ayurveda and Homoeopathy can be considered as best cure and promising treatment with no side effects. PCOS isbecoming a more prevalent disorder among women of reproductive age with lifelong complications. In the future, researchin the area of genetics and pathophysiology of PCOS is needed to determine preventive risk factors as well as successfultreatment modalities for this syndrome.
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4. | HEPATOPROTECTIVE ACTIVITY OF CHLOROFORM EXTRACT OF LEAVES OF BARLERIA GIBSONII AGAINST CARBON TETRA CHLORIDE INDUCED HEPATOTOXICITY IN RATS |
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C.R.Akila1, Gazala Perveen and G.Jeyabalan |
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Article Type:Research Article/
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No of Download=459 |
Pages (23-28) |
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The aim of the study is to investigate the hepatoprotective activity of Chloroform extract of leaves of Barleria gibsonii against Carbon tetrachloride induced hepatotoxicity. The phytochemical screening was carried on the leaves extracts of Barleria gibsonii revealed the presence of some active ingredients such as Carbohydrates, Tannins, Saponines, Phenols, steroids, terpenoids and flavonoids. Leaves of Barleria gibsonii was successively extracted with Chloroform and it is treated against Carbon tetra Chloride (0.8 ml / kg i.p) induced hepatotoxicity using Standard drug Silymarin (100mg/kg). There was a significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), Serum alanine phosphatase (SALP), reduces serum bilirubin, Cholesterol and triglyceride levels and reduces the total proteins and albumin content) in carbon tetra chloride treated rats, which were restored towards normalization in Barleria gibsonii (250 mg/kg, 400 mg /kg and 500 mg/kg) treated animals. Thus the present study ascertains that the Chloroform leaf extract of Barleria gibsonii possesses significant hepatoprotective activity.
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5. | SOLATION AND CHARACTERIZATION OF RUTIN FROM TAGETES ERECTA L |
| Kamshetti Manoj Vidyadhar, Hemant Kumar Sharma |
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Article Type:Research Article/
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No of Download=366 |
Pages (29-33) |
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Tagetes erecta L. is a widespread garden plant that is commonly known as the marigold, and it is widely used as a medicinal herb for its anti-inflammatory, analgesic, and anti-edematous properties, which are important for phytotherapeutic, dermatological and cosmetic applications. Rutin is that the major flavonoid glycoside found in gingko is that the rhamno glucoside of the flavonoid quercetin has been referred to as vitamin P or the porousness issue. Many studies had been done for the isolation of rutin by completely different chromatographically methodology. During this study rutin was isolated Tagetes erecta L. by precipitation and fractional solubilization. The isolated rutin was known by measure its melting point, ultraviolet absorption, FTIR spectra, HPLC and TLC.
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6. | ANTIDIABETIC, ANTIHYPERLIPIDAEMIC ACTIVITY OF METHANOLIC EXTRACT OF LANTANA CAMARA L LEAVES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS |
| T. Loganathan, Raghvendra Singh Bhadauria |
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Article Type:Research Article/
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No of Download=4533 |
Pages (34-42) |
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The aim of the present study was to evaluate the antihyperglycemic and antihyperlipidemic activities of methanolic extract of Lantana camara Linn leaves (MELC) in streptozotocin (STZ) - induced diabetic rats. Diabetic rats were treated with oral administration of MELC (200 and 400 mg/kg) for 21 days. Various biochemical parameters such as serum glucose, plasma insulin, Glycosylated hemoglobin (HbA1C), lipid profiles, and liver marker enzymes were measured to assess the antihyperglycemic and antihyperlipidemic activities of the extract. Administration of the MELC (200 mg/kg and 400 mg/kg) significantly decreased (P < 0.05; P < 0.01) blood glucose levels in diabetic rats and has the capacity to correct the metabolic disturbances associated with diabetes. Moreover, the decreased in body weight of rats after induction of diabetes, and increased in body weight of rats after treatment with MELC was observed. Further, the extract decreased total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very LDL (VLDL) levels, and increased high-density lipoprotein (HDL) levels. At the same time MELC treated diabetic rats, reduction in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatise (ALP) activities may be due to the presence of flavonoids and tannins in the plant extract, which repairs the tissue damage induced by diabetic complications. The present investigation suggested that the administration of MELC exhibited antidiabetic activity in STZ-induced diabetic rats and could be considered for further evaluation in drug development
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7. | PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF HYDROETHANOLIC EXTRACT OF SOLANUM XANTHOCARPUM |
| Ratnesh Singh, Chandra Kishore Tyagi, Hemant K. Sharma |
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Article Type:Research Article/
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No of Download=354 |
Pages (43-48) |
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Herbal products are extensively used globally for the treatment of many diseases where allopathic fails or has severe side effects. Psycho neural drugs are also have very serious side effects like physical dependence, tolerance, deterioration of cognitive function and effect on respiratory, digestive and immune system. So in his contest the treatment through natural source is seen with the hope that they have the lesser side effects than that observed with synthetic drugs
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8. | ACACIA VISCO-INVESTIGATIONS OF ACUTE AND CHRONIC TOXICITY |
| B. Naveen*, A. Anil kumar, G Abhilash, K Raja Sheker, C.R.Akila |
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Article Type:Research Article/
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No of Download=317 |
Pages (49-52) |
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Acacia visco is a perennial tree found at higher elevations in northern Argentina, Bolivia, Chile and Peru. It has also been introduced to Africa. Common names for it include arca, visco, viscote, viscote blanco and viscote negro. It grows 6– 25m tall and it has fragrant yellow flowers in the Spring. In Bolivia is found at an altitude of 1500–3000m. It has light to dark reddish brown twigs and small white flowers. It is cultivated for use in cabinetmaking. This study focuses on establishing the toxicity profile of the plant extract. The plant extract will be tested for acute and chronic toxicity as per OECD guidelines. The present investigation demonstrates that at doses consumed in the traditional medicine, the ethanol extract of Acacia visco L. may be considered as relatively safe, as it did not cause either any lethality or changes of in the general behavior in both the acute and chronic toxicity studies in rats
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