Traditional medicine [also known as indigenous or folk medicine] comprises medical aspects of traditional
knowledge that developed over generations within various societies before the era of modern science. The WHO defines
traditional medicine as “ the sum total of the knowledge, skills and practices based on the theories, beliefs, and experiences
indigenous to different cultures, whether applicable or not, used in the maintenance of health as well as in the prevention,
diagnosis, improvement or treatment of physical and mental illness. World community is facing an unprecedented pandemic
of novel corona virus disease[COVID-19] caused by Severe Acute Respiratory Syndrome Corona virus 2 [SARS-COV-2].
The disease has spread globally. The dimensions of pandemic require an urgent harnessing of all knowledge systems available
globally. Utilization of Traditional Chinese Medicine in Wuhan to treat COVID-19 cases sets the example demonstrating the
traditional health care can contribute to the treatment of these patients successfully. Notwithstanding the fact that no system of
medicine has any evidence based treatment for COVID-19 as yet, clinical interventions are required to be put in place.
Therefore, Traditional drugs could be implemented and be used in the treatment of COVID-19.

Epilepsy is the CNS disorder in which brain activity becomes abnormal causing seizures, and period of unusual
behavior,loss of awareness and sensation. The world population are affected by 0.5 to 1% . The mechanism of epileptic
seizures are excessive and abnormal neuronal activity in the brain of the cortex. The most common type of seizures are
convulsive, generalized seizures and partial seizures. The present study was reported to identify the effect of Celastrus
paniculata in rats brain of biogenic amine levels after induced seizures of MES & PTZ models. In Celastrus paniculata extract
treated rats, monoamines such as NA, DA, 5-HT and GABA levels significantly restored on forebrain. Thus EECP increases
the seizure threshold and decreased the susceptibility to MES and PTZ induced seizure in rats. Hence we suggest that ethanol
extract of leaves of Celastrus paniculata L. possess antiepileptic properties that may be due to restored the biogenic amines in
rat brain

Staphylococcus aureus isolates secrete coagulases, polypeptides capable of binding to and activating prothrombin, causing fibrinogen to be converted to fibrin, which then promotes clotting. While staphylococci are pathogens, they cause similar modifications of the coagulation cascade during host infection by their products, canonical coagulase (Coa) and von Willebrand factor binding protein (vWbp). In addition to leading to abscesses and bacterial persistence in host tissues, the staphylococcus binds to fibrinogen or fibrin, which is also responsible for causing lethal sepsis. There is evidence that the cellbound staphylococci, produced by coagulase activity, can cause these infections to develop into thromboembolic lesions and to resist opsonophagocytic clearance by the body's immune system. Also, the thrombin-mediated coagulation products of staphylococci appear to display distinct differences from those of staphylococci, showing these latter products represent one of the most effective innate defense mechanisms against many invading pathogens. According to preclinical studies, inactivation or neutralization of coagulases may prevent the formation of staphylococcal infections, a strategy that could be used to combat hospital-acquired infections caused by drug-resistant Staphylococcus aureus isolates