Hyperlipidemia is characterized by an elevated level of lipids, including cholesterol and triglycerides, in the plasma, which increases the risk for cardiovascular diseases. It involves the disruption of lipid homeostasis, where an imbalance between different lipoproteins—chylomicrons, VLDL, LDL, and HDL—can lead to pathological conditions. Cholesterol, both exogenous and endogenous, plays a critical role in cellular functions, such as membrane fluidity, hormone synthesis, and bile salt production. Triglycerides, the body's main energy reserves, are primarily stored in adipose tissue and serve as an energy source when needed. The absorption of dietary lipids occurs in the small intestine, where pancreatic lipase hydrolyzes dietary fats, and chylomicrons are formed for fat transport. Lipoproteins, such as VLDL and LDL, transport triglycerides and cholesterol to tissues, while HDL functions in reverse cholesterol transport, returning excess cholesterol to the liver for metabolism. Understanding the complex interplay between lipoproteins and lipid metabolism is crucial for developing therapeutic strategies for hyperlipidemia, such as statins and other lipid-lowering agents

This study investigates the therapeutic potential of the methanolic extract of Maesa lanceolata (MEML) in managing Parkinson's disease (PD) symptoms, using a rat model of haloperidol-induced catalepsy. MethodWe assessed the anticonvulsant effects of MEML and its impact on exploratory behaviors in haloperidol-treated rats, comparing the effects with the standard PD drug, benztropine. Rats were divided into different groups and administered either MEML or haloperidol alone. Catalepsy and exploratory behaviors were monitored at various time intervals. Resultsdemonstrated that MEML, at a dose of 400 mg/kg, significantly reduced the catalepsy scores in treated rats, exhibiting an anticataleptic effect comparable to that of the standard drug. Furthermore, MEML significantly enhanced exploratory behaviors, including head dipping and line crossing activities, in haloperidol-treated rats. These behaviors, typically diminished during catalepsy, are indicative of motor and coordination capabilities, suggesting that MEML could also alleviate these PD symptoms. We hypothesize that the observed effects of MEML may be attributed to its potential regulation of neurotransmitters, including dopamine, serotonin, and glutamate, as well as antioxidant enzyme systems. Conclusion- findings highlight the value of exploring plant-based treatments in neurodegenerative diseases, setting the foundation for future investigations. However, to corroborate these findings and unravel the precise mechanisms of action, further comprehensive studies on different extracts and isolated principles of Maesa lanceolata are warranted